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Anti-Inflammatory Killers *LINK*
In Response To: Re: Fulla Nayak ()

Tuesday September 13,2011

By Nathan Rao

TAKING a popular type of painkiller for more than 10 years brings a three-times higher chance of getting kidney cancer, scientists said yesterday.

A study of more than 125,000 adults found people who took non-steroidal anti-inflammatory drugs – which include ibuprofen, diclofenac, and naproxen – were overall 51 per cent more likely to develop the disease.

But those who took them for more than a decade almost tripled their risk of suffering renal cell cancer, the most common form of kidney cancer, American researchers found.

Aspirin was the only one of the group of medications, used long-term to treat inflammatory conditions such as arthritis, found not to increase the risk.

The research, published in this month’s edition of Archives of Internal Medicine, was carried out by Dr Eunyoung Cho and colleagues at ­Harvard Medical School and Brigham and Women’s Hospital, Boston.

Dr Cho said: “In these large studies of women and men, we found that use of non-aspirin NSAIDs was associated with an elevated risk of renal cell ­cancer, especially among those who took them for a long duration.”

The team analysed data from 77,525 women and 49,403 men whose use of aspirin and other NSAIDs was recorded for up to 20 years.

During that time 333 developed renal cell cancer. In people who had taken NSAIDs for under four years there was actually a 19 per cent decrease in the risk of developing the disease.

There was a 26 per cent increase in risk for people who used them for between four and 10 years, with the risk tripling after 10 or more years of constant use.

The overall risk of renal cell cancer remains small in comparison with that of other major diseases.

Just six out of every 100,000 people are expected to develop the condition compared with 204, 44, and 95 per 100,000 for fatal heart disease, colo­rectal cancer and Alzheimer’s.

Renal cell cancer accounts for around two per cent of all cancers diagnosed in the UK, although it is difficult to treat, with a cure rate of about a third.

It is the second time this month that NSAIDs have been associated with health risks.

A study published in the Canadian Medical Association Journal found they increased the risk of miscarriage in the first 20 weeks of pregnancy.

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